Our Research Results

Publications

  1. Li JW, Lee HM, Wang Y, Tong AH, Yip KY, Tsui SK, Lok S, Ozaki R, Luk AO, Kong AP, So WY, Ma RC, Chan JC, Chan TF. Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes. Sci Rep 2016; Oct 18; 6: 35228
    https://www.ncbi.nlm.nih.gov/pubmed/27752041
     
  2. Ma RC, Schmidt MI, Tam WH, McIntyre HD, Catalano PM. Clinical management of pregnancy in the obese mother: before conception, during pregnancy, and post partum. Lancet Diabetes Endocrinol 2016; Oct 10
    https://www.ncbi.nlm.nih.gov/pubmed/27743977
     
  3. Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR, Gaulton KJ, Grarup N, Bradfield JP, Strachan DP, Li-Gao R, Ahluwalia TS, Kreiner E, Rueedi R, Lyytikäinen LP, Cousminer DL, Wu Y, Thiering E, Wang CA, Have CT, Hottenga JJ, Vilor-Tejedor N, Joshi PK, Boh ET, Ntalla I, Pitkänen N, Mahajan A, van Leeuwen EM, Joro R, Lagou V, Nodzenski M, Diver LA, Zondervan KT, Bustamante M, Marques-Vidal P, Mercader JM, Bennett AJ, Rahmioglu N, Nyholt DR, Ma RC, Tam CH, Tam WH; CHARGE Consortium Hematology Working Group., Ganesh SK, van Rooij FJ, Jones SE, Loh PR, Ruth KS, Tuke MA, Tyrrell J, Wood AR, Yaghootkar H, Scholtens DM, Paternoster L, Prokopenko I, Kovacs P, Atalay M, Willems SM, Panoutsopoulou K, Wang X, Carstensen L, Geller F, Schraut KE, Murcia M, van Beijsterveldt CE, Willemsen G, Appel EV, Fonvig CE, Trier C, Tiesler CM, Standl M, Kutalik Z, Bonàs-Guarch S, Hougaard DM, Sánchez F, Torrents D, Waage J, Hollegaard MV, de Haan HG, Rosendaal FR, Medina-Gomez C, Ring SM, Hemani G, McMahon G, Robertson NR, Groves CJ, Langenberg C, Luan J, Scott RA, Zhao JH, Mentch FD, MacKenzie SM, Reynolds RM; Early Growth Genetics (EGG) Consortium., Lowe WL, Tönjes A, Stumvoll M, Lindi V, Lakka TA, van Duijn CM, Kiess W, Körner A, Sørensen TI, Niinikoski H, Pahkala K, Raitakari OT, Zeggini E, Dedoussis GV, Teo YY, Saw SM, Melbye M, Campbell H, Wilson JF, Vrijheid M, de Geus EJ, Boomsma DI, Kadarmideen HN, Holm JC, Hansen T, Sebert S, Hattersley AT, Beilin LJ, Newnham JP, Pennell CE, Heinrich J, Adair LS, Borja JB, Mohlke KL, Eriksson JG, Widén E, Kähönen M, Viikari JS, Lehtimäki T, Vollenweider P, Bønnelykke K, Bisgaard H, Mook-Kanamori DO, Hofman A, Rivadeneira F, Uitterlinden AG, Pisinger C, Pedersen O, Power C, Hyppönen E, Wareham NJ, Hakonarson H, Davies E, Walker BR, Jaddoe VW, Järvelin MR, Grant SF, Vaag AA, Lawlor DA, Frayling TM, Smith GD, Morris AP, Ong KK, Felix JF, Timpson NJ, Perry JR, Evans DM, McCarthy MI, Freathy RM. Genome-wide association of birth weight and correlations with adult disease. Nature 2016; Sept 28; 538 (7624): 248-252.
    https://www.ncbi.nlm.nih.gov/pubmed/27680694
     
  4. Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Fernandez Tajes J, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SC, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MC, Palmer ND, Balkau B, Stancáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VK, Park KS, Saleheen D, So WY, Tam CH, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, van der Schouw YT, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA Jr, Thameem F, Wilson G Sr, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney AS, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, Hrabé de Angelis M, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CN, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RC, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJ, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuler D, McCarthy MI. The genetic architecture of type 2 diabetes. Nature 2016; 536 (7614): 41-7.
    https://www.ncbi.nlm.nih.gov/pubmed/27398621
     
  5. Horikoshi M, Pasquali L, Wiltshire S, Huyghe JR, Mahajan A, Asimit JL, Ferreira T, Locke AE, Robertson NR, Wang X, Sim X, Fujita H, Hara K, Young R, Zhang W, Choi S, Chen H, Kaur I, Takeuchi F, Fontanillas P, Thuillier D, Yengo L, Below JE, Tam CH, Wu Y, Abecasis G, Altshuler D, Bell GI, Blangero J, Burtt NP, Duggirala R, Florez JC, Hanis CL, Seielstad M, Atzmon G, Chan JC, Ma RC, Froguel P, Wilson JG, Bharadwaj D, Dupuis J, Meigs JB, Cho YS, Park T, Kooner JS, Chambers JC, Saleheen D, Kadowaki T, Tai ES, Mohlke KL, Cox NJ, Ferrer J, Zeggini E, Kato N, Teo YY, Boehnke M, McCarthy MI, Morris AP; T2D-GENES Consortium. Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Human Molecular Genetics 2016; May 25(10): 2070-2081
    https://www.ncbi.nlm.nih.gov/pubmed/26911676
     
  6. W. Jiang and W. Yu*. Power Estimation and Sample Size Determination for Replication Studies of Genome-Wide Association Studies, BMC Genomic 2016s, 17(Suppl 1):3.
    https://www.ncbi.nlm.nih.gov/pubmed/26818952
     
  7. F.Yu, N. Li, W. Yu. ECL: An Exhaustive Search Tool for the Identification of Cross-Linked Peptides Using Whole Database. BMC Bioinformatics 2016, 17:217.
    https://www.ncbi.nlm.nih.gov/pubmed/27206479
     
  8. X. Zhu, F. Yu, Z. Yang, C. Dai, X. Lu, W. Yu*, and N. Li*. In planta chemical cross-linking and mass spectrometry analysis of protein structure and interaction in Arabidopsis. Proteomics 2016; 16:1915-1927.
    https://www.ncbi.nlm.nih.gov/pubmed/27198063
     
  9. You YK, Huang XR, Chen HY, Lyu XF, Liu HF*, Lan HY*. C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway. Sci Rep 2016; 25(6): 26740
    https://www.ncbi.nlm.nih.gov/pubmed/27221338
     
  10. Zhou Q, Xiong Y, Huang XR, Tang P, Yu X, Lan HY*. Identification of Genes Associated with Smad3-dependent Renal Injury by RNA-seq-based Transcriptome Analysis. Sci Rep. 2016; 5:17901.
    https://www.ncbi.nlm.nih.gov/pubmed/26648110
     
  11. Zhang H, Liu J, Qu J, Wang L, Luo JY, Lau CW, Liu P, Gao Z, Tipoe GL, Lee HK, Ng CF, Ma RC, Yao X, Huang Y*. Inhibition of miR-200c restores endothelial function in diabetic mice through suppression of COX-2. Diabetes 2016; 65(6): 1197-207
    https://www.ncbi.nlm.nih.gov/pubmed/26822089
     
  12. Imamura M, Takahashi A, Yamauchi T, [12 authors], Ma RC, [18authors], Tam CH, [9 authors], Chan JC, [11 authors], Maeda S*, Kadowaki T*. Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. Nat Commun 2016; 28(7): 10531
    https://www.ncbi.nlm.nih.gov/pubmed/26818947
     
  13. Nanditha A, Ma RC, Ramachandran A, Snehalatha C, Chan JC, Chia KS, Shaw JE, Zimmet PZ*. Diabetes in Asia and the Pacific: Implications for the Global Epidemic. Diabetes Care 2016; 39(3): 472-85.
    https://www.ncbi.nlm.nih.gov/pubmed/26908931
     
  14. Jiang G, Hu C, Tam CH, [10authors], Tsui SK, Ng MC, Szeto CC, Jia W, Fan X, So WY, Chan JC, Ma RC*. Genetic and Clinical Variables identify predictors of chronic kidney disease in type 2 diabetes. Kid Int 2016; 89(2): 411-20
    https://www.ncbi.nlm.nih.gov/pubmed/26806836
     
  15. Jiang G, Luk AO, Yang X, Wang Y, Tam CH, Lau SH, Ozaki R, Kong AP, Tong PC, Chow CC, Chan JC, So WY, Ma RC*. Progression to treatment failure among Chinese patients with type 2 diabetes initiated on metformin versus sulphonylurea monotherapy. Diab Res Clin Pract 2015; Nov 23
    https://www.ncbi.nlm.nih.gov/pubmed/26703273
     
  16. Liu J, Wang L, Tian XY, Liu LM, Wong WT, Zhang Y, Han Q, Ho HM, Wang N, Wong, SL, Chen ZY, Yu J, Ng CF, Yao X & Huang Y. Unconjugated bilirubin mediates heme oxygenase-1-induced vascular benefits in diabetic mice. Diabetes 2015; 64(5):1564-1575 with commentary 64(5):1506-1508.
    https://www.ncbi.nlm.nih.gov/pubmed/25475440
     
  17. Zhang Y, Liu J, Luo JY, Tian XY, Cheang WS, Xu J, Lau CW, Wang L, Wong WT, Wong CM, Lan HY, Yao XQ, Raizada MK & Huang Y. Upregulation of angiotensin (1-7)-mediated signaling preserves endothelial function through reducing oxidative stress in diabetes. Antioxidants & Redox Signaling 2015 Apr 13.
    https://www.ncbi.nlm.nih.gov/pubmed/25867182
     
  18. Meng XM, Tang PM, Li J, Lan HY. TGF-β/Smad signaling in renal fibrosis. Front Physiol. 2015 Mar 19;6:82.
    https://www.ncbi.nlm.nih.gov/pubmed/25852569
     
  19. Zhou Q, Huang XR, Yu J, Yu X, Lan HY. Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation. Mol Ther. 2015 Jun;23(6):1034-43.
    https://www.ncbi.nlm.nih.gov/pubmed/25743111
     
  20. Wang G, Lai FM, Chow KM, Kwan BC, Pang WF, Luk CC, Leung CB, Li PT, Szeto CC. Urinary mRNA Levels of ELR-Negative CXC Chemokine Ligand and Extracellular Matrix in Diabetic Nephropathy. Diabetes/Metabolism Research and Reviews, 2015 (doi: 10.1002/dmrr.2654; PMID: 25941061).
    https://www.ncbi.nlm.nih.gov/pubmed/25865428
     
  21. Yang G, Jiang W, Yang Q, Yu W. PBOOST: A GPU-based tool for parallel permutation tests in genome-wide association studies. Bioinformatics, 31(9):1460-2, 2015.
    https://www.ncbi.nlm.nih.gov/pubmed/25535244
     
  22. Ma RC. Genetics of Cardiovascular and Renal Complications in Diabetes. J Diab Invest 2016; 7(2): 139-154
    https://www.ncbi.nlm.nih.gov/pubmed/27042264
     
  23. Ma RC, Xu G. Incretin action on bone: An added benefit? J Diab Invest 2015; 6(3): 267-8.
    https://www.ncbi.nlm.nih.gov/pubmed/25969710
     
  24. Hwang JY, Sim X, Wu Y, Liang J, Tabara Y, Hu C, Hara K, Tam CH, Cai Q ,Zhao Q, Jee S, Takeuchi F, Go MJ, Ong RTH, Ohkubo T, Kim YJ, Zhang R, Yamauchi T, So WY, Long J, Gu D, Lee NR, Kim S, Katsuya T, Oh JH, Liu J, Umemura S, Kim Y-J, Jiang F, Maeda S, Chan JC, Lu W, Hixson JE, Adair LS, Jung KJ, Nabika T, Bae J-B, Lee MH, Seielstad M, Young TL, Teo YY, Kita Y, Takashima N, Osawa H, Lee S-H, Shin M-H, Shin DH, Choi BY, Shi J, Gao Y-T, Xiang T-B, Zheng W, Kato N, Yoon M, He J, Shu XO, Ma RC, Kadowaki T, Jia W, Miki T, Qi L, Tai ES, Mohlke KL, Han B-G, Cho YS, Kim B-J.Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians. Diabetes 2015; 64: 291-298.
    https://www.ncbi.nlm.nih.gov/pubmed/25187374
     
  25. Ma RC, Lin X, Jia WP. Causes of Type 2 Diabetes in China. Lancet Diabetes Endocrinol 2014; 2(12): 980-91.
    https://www.ncbi.nlm.nih.gov/pubmed/25218727